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KMID : 0545120070170101717
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Journal of Microbiology and Biotechnology
2007 Volume.17 No. 10 p.1717 ~ p.1720
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Cyclo(Dehydrohistidyl-L-Tryptophyl), an Inhibitor of Nitric Oxide Production from a Fungal Strain, Fb956
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Noh Hyun-Jeong
Kim Won-Gon
Sohn Mi-Jin
Yu Hyung-Eun
Yoo Ik-Dong
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Abstract
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In the course of screening for nitric oxide inhibitors in activated microglial BV-2 cells, cyclo(dehydrohistidyl-Ltryptophyl) was isolated from solid-state fermentation cultures of an unidentified fungal strain, Fb956. Its structure was determined by spectroscopic methods including 2D NMR and chiral TLC analyses. Cyclo(dehydrohistidyl-L-tryptophyl) was found to have an inhibitory activity on nitric oxide production with an IC50 of 6.5 mM in activated BV-2 cells. The structure determination and biological activity of cyclo(dehydrohistidyl- L-tryptophyl) was reported for the first time in this study.
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KEYWORD
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Cyclo(dehydrohistidyl-L-tryptophyl), cyclic peptide, nitric oxide, microglia
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